2D QSAR STUDIES ON THE DIFFERENTIAL INHIBITION OF ALDOSE REDUCTASE BY FLAVONIODS COMPOUNDS:A COMPARATIVE STUDY
نویسندگان
چکیده
منابع مشابه
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Inhibition of Aldose Reductase by Gentiana lutea Extracts
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes. Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications. Gentiana lutea grows naturally in the central and southern areas of Europe. Its roots are commonly consume...
متن کاملInhibition of aldose reductase and sorbitol accumulation by dietary rutin
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2 or AKR1B1) activity has been implicated in the development of various secondary complications of diabetes. Previously we have reported that some common dietary sources such as spices, fruits and vegetables have the potential to inhibit ALR2 under in vitro conditions and in animal models. In this study, we describe th...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2014
ISSN: 2250-1177
DOI: 10.22270/jddt.v4i2.790